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Pyrazomycin是一种核苷类抗菌素。由Streptomyces candidus所产生。体外试验有抗真菌作用,同时对牛痘病毒、单纯疱疹病毒、麻疹病毒等都有抑制作用。由于对Friend白血病病毒具有抑制作用,因而把它作为实验性抗肿瘤药物进行估价。 Pyrazomycin为水溶性,采用腹腔注射、口服、肌肉注射和静脉注射等四种给药途径,剂量为10毫克/公斤,每隔二天、三天、四天、五天给药一次,能完全抑制大鼠瓦克氏癌256的生长。对小鼠乳腺癌755,Gardner淋巴肉瘤和浆细胞骨髓瘤的抑制率在50%以上。对
Pyrazomycin is a nucleoside antibiotic. Produced by Streptomyces candidus. In vitro tests have anti-fungal effects, while the vaccinia virus, herpes simplex virus, measles virus and so has an inhibitory effect. It is evaluated as an experimental antitumor drug due to its inhibitory effect on Friend Leukemia virus. Pyrazomycin is water-soluble. It is administered by four routes of administration: intraperitoneal injection, oral administration, intramuscular injection and intravenous injection at a dose of 10 mg / kg given once every two days, three days, four days and five days, Rat Wacker’s cancer 256 growth. The inhibition rate on mouse breast cancer 755, Gardner lymphosarcoma and plasma cell myeloma is more than 50%. Correct