论文部分内容阅读
目的:验证雌激素对雄性大鼠缺血性卒中的神经保护作用。方法:采用雄性Sprague-Dawley大鼠实验性大脑中动脉闭塞(middle cerebral artery occlusion,MCAO)模型作为研究对象。分为3组:生理浓度雌激素长期应用组、超生理浓度雌激素即刻使用组、对照组,每组又各分为两小组。均建立动物模型后进行相应药物干预,观察各组脑梗塞体积占同侧半球体积的百分比、死亡率及症状行为学改变、病理形态学及超微结构的改变以及脑水肿含量并分析比较。结果 生理浓度雌激素长期应用组、超生理浓度雌激素即刻使用组较对照组脑梗塞体积比明显减小(P<0.05);死亡率降低、症状雄行为学改善、病理形态学及超微结构破坏减轻、脑水肿含量减少。结论 雌激素对雄性大鼠缺血性卒中具有神经保护作用。
Objective: To verify the neuroprotective effects of estrogen on ischemic stroke in male rats. Methods: Experimental middle cerebral artery occlusion (MCAO) model of male Sprague-Dawley rats was used as the research object. Divided into three groups: physiological concentrations of estrogen long-term application group, ultra-physiological concentration of estrogen immediate use group, control group, each group is divided into two groups. The animal models were established after the corresponding drug intervention, the percentage of cerebral infarction volume accounting for the ipsilateral hemisphere volume, mortality and symptoms and behavioral changes, pathological and ultrastructural changes and brain edema content were analyzed and compared. Results Long-term application of physiological concentrations of estrogen showed that the volumes of cerebral infarction in the estrogen-treated group at the time of super-physiological estrogen treatment were significantly lower than those in the control group (P <0.05), the mortality was decreased, the symptoms were improved, the pathology and ultrastructure Reduce damage, reduce brain edema content. Conclusion Estrogen has neuroprotective effects on ischemic stroke in male rats.