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目的探讨2型糖尿病患者糖化血红蛋白水平对干眼的影响。方法收集140例2型糖尿病患者,根据糖化血红蛋白(Hb A1c)水平,将其分为血糖控制稳定组(70例)和血糖控制不佳组(70例),分别问询干眼症状并测定泪液分泌试验(SIt)、泪膜破裂时间(BUT)及角膜荧光素染色(FL),对两组干眼症状和各项检查结果进行统计学分析。结果血糖控制不佳组老年患者及男性患者干眼症状的发生率明显高于血糖控制稳定组。两组泪膜功能检查:血糖控制不佳组老年男性及女性患者与血糖控制稳定组相比,泪液分泌试验(SIt)、泪膜破裂时间(BUT)降低,差异均有统计学意义(P<0.05);两组中青年患者的SIt、BUT差异无统计学意义(P>0.05)。各亚组的角膜荧光素染色(FL)检查结果无明显差别(P>0.05)。Hb A1c水平与老年糖尿病患者的干眼症状发生率呈正相关,与SIt、BUT结果呈负相关。结论 2型糖尿病老年患者的Hb A1c水平与干眼相关,控制其Hb A1c水平有助于改善干眼症状。
Objective To investigate the effect of HbA1c on dry eye in type 2 diabetic patients. Methods 140 patients with type 2 diabetes mellitus were divided into two groups according to the level of Hb A1c: stable blood glucose control group (70 cases) and poor blood glucose control group (70 cases). The symptoms of dry eye and tear fluid Secretory test (SIt), tear film break-up time (BUT) and corneal fluorescein staining (FL). The dry eye symptoms and the results of the two groups were statistically analyzed. Results The incidence of dry eye symptoms in elderly patients and male patients with poor glycemic control was significantly higher than that in stable patients with glycemic control. Two groups of tear film function tests: poor blood glucose control group of elderly men and women compared with stable glucose control group, tear secretion test (SIt), tear film rupture time (BUT) decreased, the differences were statistically significant (P < 0.05). There was no significant difference in SIt and BUT between the two groups (P> 0.05). Corneal fluorescein staining (FL) test results of each subgroup no significant difference (P> 0.05). The level of Hb A1c was positively correlated with the incidence of dry eye symptoms in elderly diabetic patients and negatively correlated with the results of SIt and BUT. Conclusion The level of Hb A1c in elderly patients with type 2 diabetes is related to dry eye. Controlling the level of Hb A1c may help to improve the symptoms of dry eye.