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自身免疫性溶血性贫血(AIHA)主要是由于免疫功能紊乱所产生自身抗体,结合在红细胞表面或游离在血清中,使红细胞致敏,或激活补体,导致红细胞破坏加速造成的获得性溶血性贫血。笔者遇到1例AIHA,伴有肝硬化(失代偿期)、十二指肠球部溃疡、慢性肾功能不全、巨脾症,进行性溶血。血红蛋白低于60 g·L~(-1),临床配血始终不配合,实验后结合临床决定对此病人输注洗涤红细胞,共输注12 U,大幅度地改善临床症状。
Autoimmune hemolytic anemia (AIHA) is mainly due to immune autoantibodies produced by autoimmune disorders, bound to the surface of red blood cells or free in serum, sensitized erythrocytes, or activate complement, resulting in accelerated red blood cell damage caused by acquired hemolytic anemia . I met 1 case of AIHA, with cirrhosis (decompensated), duodenal ulcer, chronic renal insufficiency, splenomegaly, progressive hemolysis. Hemoglobin less than 60 g · L ~ (-1), the clinical blood with the match does not always match with the clinical decision after the infusion of washed red blood cells in this patient, a total infusion of 12 U, significantly improve clinical symptoms.