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目的对比雷尼替丁和奥美拉唑治疗非甾体类抗炎药相关性胃溃疡的疗效,分析幽门螺杆菌(Hp)感染与非甾体类抗炎药相关性胃溃疡治愈率的关系,探讨非甾体类抗炎药相关性胃溃疡的最佳治疗方法。方法患者随机分成两组,分别口服盐酸雷尼替丁150 mg每天两次、奥美拉唑20 mg每天1次。通过14C尿素呼气试验(14C-UBT)确定Hp阳性患者。结果轻中度腹痛雷尼替丁组55.6%(55/99),奥美拉唑组57.6%(57/99)。第6周治愈率雷尼替丁组51.5%(51/99),奥美拉唑组73.7%(73/99),两组相比差异有统计学意义(P<0.05)。经过6周的抑酸治疗,幽门螺杆菌阳性溃疡患者治愈率雷尼替丁组53.5%(53/99),奥美拉唑组为70.7%(70/99);幽门螺杆菌阴性溃疡患者治愈率雷尼替丁组49.5%(49/99),奥美拉唑组75.8%(75/99)。结论治疗非甾体类抗炎药相关性溃疡口服奥美拉唑效果优于雷尼替丁;Hp感染不会延迟非甾体类抗炎药相关性胃溃疡的治愈。
Objective To compare the efficacy of ranitidine and omeprazole in the treatment of non-steroidal anti-inflammatory drug-related gastric ulcer and to analyze the relationship between Helicobacter pylori (Hp) infection and the cure rate of non-steroidal anti-inflammatory drug-related gastric ulcer , To explore the best treatment of non-steroidal anti-inflammatory drug-related gastric ulcer. Methods Patients were randomly divided into two groups: oral ranitidine hydrochloride 150 mg twice daily and omeprazole 20 mg daily. Hp positive patients were determined by 14C urea breath test (14C-UBT). Results 55.6% (55/99) in ranitidine group and 57.6% (57/99) in omeprazole group had mild to moderate abdominal pain. The cure rate in the sixth week was 51.5% (51/99) in the ranitidine group and 73.7% (73/99) in the omeprazole group, the difference was statistically significant (P <0.05). After 6 weeks of acid suppression, the cure rate of Helicobacter pylori positive ulcer patients was 53.5% (53/99) in ranitidine group and 70.7% (70/99) in omeprazole group, and the patients with H. pylori negative ulcer were cured The rate of ranitidine group 49.5% (49/99), omeprazole group 75.8% (75/99). Conclusion The treatment of non-steroidal anti-inflammatory drug-related ulcer oral omeprazole better than ranitidine; Hp infection does not delay the non-steroidal anti-inflammatory drug-related gastric ulcer cure.