体内微核试验作为检测遗传毒性的方法,已广泛用于毒理学研究。作者对此曾作过简要的专题介绍。Haddle等1981年发表了体外微核试验方法。并建议在用于阅读姐妹染色单体交换(SCE)的玻片上,同时检查受试细胞的微核率。本文报道用V79细胞的体外微核试验,对16种化学物所作的遗传毒性的评价结果,同时对其中大部分化学 In vivo micronucleus test, as a method of detecting genotoxicity, has been extensively used in toxicological studies. The author made a brief presentation on this topic. Haddle et al. Published the in vitro micronucleus test method in 1981. It is also recommended to check the micronucleus rate of the test cells on the slide used to read Sister Chromatid Exchange (SCE). This article reports the in vitro micronucleus test of V79 cells, the results of the evaluation of the genotoxicity of 16 chemicals, and most of the chemical