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目的:探讨雷公藤多苷片联合克龄蒙对多囊卵巢综合征患者的疗效。方法:收集已生育且无生育要求的多囊卵巢综合征患者30例,给予雷公藤多苷片和克龄蒙片。分别于月经第2天测定性激素6项、血常规、肝肾功能以及经阴道超声。结果:经3个周期治疗后,子宫体积与第1月经周期相比,体积增大(P<0.05);卵巢体积和平均窦卵泡个数明显减少(P<0.01)。性激素水平检测显示,第四月经期的FSH比与第一月经周期相比,水平降低(P<0.05),而LH和T水平则是明显降低(P<0.05)。肝肾功能及血常规结果在治疗前后无明显变化(P>0.05)。结论:雷公藤多苷片联合克龄蒙可以有效治疗多囊卵巢综合征,其具体机制可能是通过多环节对卵巢和子宫发挥免疫抑制作用。
Objective: To investigate the effect of Tripterygium Wilfordii polyglucoside tablets combined with Kelong on polycystic ovary syndrome patients. Methods: 30 cases of polycystic ovary syndrome who had fertility and no fertility requirements were collected and given Tripterygium Wilfordii glycosides tablets and Kelong mask tablets. On the second day of menstruation, 6 sex hormones, blood routine, liver and kidney function and transvaginal ultrasound were measured respectively. Results: After three cycles of treatment, the volume of uterus increased compared with that of the first menstrual cycle (P <0.05), and the volume of ovary and the mean number of antral follicles decreased significantly (P <0.01). The level of FSH in the fourth menstrual period was lower than that in the first menstrual cycle (P <0.05), while the levels of LH and T were significantly decreased (P <0.05). Liver and kidney function and blood test results before and after no significant change (P> 0.05). Conclusion: Tripterygium glycosides tablets combined with Kelin Meng effective treatment of polycystic ovary syndrome, the specific mechanism may be through multiple links to ovarian and uterine immunosuppressive effect.