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目的：对腰椎间盘突出症患者采取胶原酶侧隐窝靶向介入配合闭合性手术的治疗方法，对其临床实际疗效进行分析探讨。方法选取我院在2013年6月～2015年5月所接收的60例腰椎间盘突出症患者作为研究对象，将其随机分为实验组和对照组，每组各有患者30例，对实验组患者采取经侧隐窝注入1200U胶原酶的治疗方法，对对照组患者采取在X光机下经椎间孔注入同等量胶原酶的方法，对实际疗效进行分期的对比分析。结果在治疗后的1月中，实验组中有1例患者的实际疗效较差，其总优良率为96.67%，而对照组的总优良率为93.33%，两组相比差异不具有统计学意义(﹥0.05)；在治疗之后的1年对复发结果进行分析，发现实验组的总优良率为96.67%，而对照组中增加了3例疗效较差的患者，其总优良率为86.67%，两组相比差异十分明显( 0.05); after 1 year of treatment for recurrent results were analyzed and found that the total fine rate was 96.67% in the experimental group, while the control group, an increase of three cases of poor efficacy in patients with total excellent rate 86.67%, compared the two groups is very significant difference ( <0.05). Conclusion The study found that taking the targeted therapy intervention with collagenase lateral recess closed surgery on lumbar disc herniation has a very significant effect of the application, it is worth to achieve further promotion and application in clinical practice.