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研究目的探讨围产儿先天畸形的发病原因，为该病的防治提供依据。研究方法对1983年7月至1993年7月在我院妇产科出生的围产儿病例进行回顾性统计分析，并进一步调查产生畸形儿的母亲。结果通过对5253例围产儿的回顾性调查分析发现，围产儿先天畸形的发生率为11.8‰，先天畸形与孕妇在前3个月内发生感染、精神创伤、孕期患慢性病及出生季节有明显关系。以神经系统畸形为多，占59.68％，其中女性多于男性，其它畸形则以男性居多。结论先天畸形与遗传和孕早期的环境因素有直接关系。
Objective To investigate the causes of congenital malformations in perinatal children and provide evidence for the prevention and treatment of this disease. METHODS: A retrospective statistical analysis of perinatal infants born in obstetrics and gynecology from July 1983 to July 1993 in our hospital was conducted and the mothers who had malformed children were investigated further. The results of retrospective survey of 5253 cases of perinatal children found that the incidence of perinatal congenital malformations was 11.8 ‰, congenital malformations and pregnant women within the first 3 months of infection, trauma, chronic diseases and gestational age were significantly related to the birth season . To the nervous system malformations for more, accounting for 59.68%, of which more women than men, other malformations are mostly men. Conclusions Congenital malformations are directly related to the genetic and environmental factors of early pregnancy.