原发性十二指肠癌(不包括起源于壶腹、胆总管下段及胰头的癌)甚少见。Hamberger于1946年首先报告1例,此后至1974年文献报道仅694例。发病率在整个胃肠道肿瘤中占0.3%,在小肠恶性肿瘤中占25～45%。早期症状无特异性,故早期诊断很困难。现将我院1970～1990年经手术或肠镜活检证实的27例原发性十二指肠癌报 Primary duodenal cancer (excluding cancer originating in the ampulla, lower common bile duct, and pancreatic head) is rare. Hamberger first reported 1 case in 1946, and only 694 cases were reported in the literature since 1974. The incidence rate is 0.3% in the entire gastrointestinal tumor and 25-45% in the small intestine malignancy. The early symptoms are not specific, so early diagnosis is difficult. The report of 27 cases of primary duodenal cancer confirmed by surgery or colonoscopy biopsy in our hospital from 1970 to 1990