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目的观察比较氯沙坦与依那普利治疗轻中度原发性高血压的临床疗效及安全性。方法选取2014年3月-2015年3月在医院就诊的轻中度原发性高血压患者148例,随机分为氯沙坦组和依那普利组各74例。氯沙坦组患者给予氯沙坦治疗;依那普利组给予依那普利治疗。治疗前后测量患者的坐位血压,并做好记录,治疗结束后对比2组患者的治疗效果及不良反应情况。结果氯沙坦组治疗的总有效率为98.6%,依那普利组治疗的总有效率为94.6%,2组比较差异无统计学意义(P>0.05)。氯沙坦组不良反应发生率为1.4%(1/74)明显低于依那普利组的13.5%(10/74),2组不良反应发生率比较差异有统计学意义(P<0.05)。结论氯沙坦是治疗轻中度原发性高血压的有效药物,并且安全性高,患者一次用药可维持24h降压效果,方便易于耐受。
Objective To compare the clinical efficacy and safety of losartan and enalapril in the treatment of mild to moderate essential hypertension. Methods A total of 148 patients with mild-to-moderate essential hypertension who were hospitalized from March 2014 to March 2015 were randomly divided into losartan group and enalapril group, 74 cases each. Losartan was given to losartan and enalapril was given to enalapril. Before and after treatment, the patient’s sitting blood pressure was measured and recorded. After treatment, the treatment effect and adverse reactions of the two groups were compared. Results The total effective rate of losartan group was 98.6%. The total effective rate of enalapril group was 94.6%. There was no significant difference between the two groups (P> 0.05). The incidence of adverse reactions in losartan group was 1.4% (1/74), which was significantly lower than that in enalapril group (13.5%, 10/74). The incidence of adverse reactions in two groups was statistically significant (P0.05) . Conclusion Losartan is an effective drug for the treatment of mild-to-moderate essential hypertension, and has high safety. The single-dose administration of losartan can maintain the hypotensive effect of 24h, which is convenient and easy to tolerate.