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本文调查了860个家庭,这些家庭中至少一位成员有Ⅰ型糖尿病(IDDM)。作者对所有非糖尿病的一级亲属(包括父母、同胞和子女)共1,723人进行研究。抽血测胰岛细胞抗体(islet-cell antibodies,ICA)。对 ICA 阳性者定期(每3个月)门诊追踪β细胞功能,并反复检测 ICA。以220名无糖尿病家族史的健康志愿者作对照。结果 1,723名一级亲属中16名 ICA 阳性。在2年随访期间,16名 ICA 阳性者中2名出现显性IDDM,其余14名 ICA 阳性者中12名进行静注葡萄
This paper investigates 860 families, at least one of whom has Type 1 diabetes (IDDM). The authors studied a total of 1,723 non-diabetic first-degree relatives (including parents, siblings and children). Blood was collected for islet-cell antibodies (ICA). ICA-positive patients regularly (every 3 months) follow-up β-cell function, and repeated testing ICA. To 220 non-diabetic family history of healthy volunteers as a control. Results Among the 1,723 first degree relatives, 16 were ICA positive. During 2 years of follow-up, 2 of 16 ICA positive individuals developed dominant IDDM, and 12 of the remaining 14 ICA positive individuals received intravenous grapes