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40只Wistar雄性大鼠分四组,1,2,3组分别皮下注入0.005,0.01,0.02mol/L,NiSO41ml/(kg.d),第四组皮下注射生理盐水作为对照。40天后0.01mol/L及0.02mol/LNiSO4组血清T3,T4均低于对照组,0.005mol/LNiSO4组T4亦低于对照组,而各剂量NiSO4组间血清T3,T4均无差异,即无剂量-效应关系。