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先前有关高血压合并高胆固醇血症患者的研究结果表明,他汀类药物可减少肌肉交感神经活性(muscle sympathetic nerve activity,MSNA),但是这些研究没有分析该机制的潜在神经节作用位点以及对血管内皮功能或胰岛素抵抗的作用。该研究以血浆胆固醇较低的高血压患者为研究对象,旨在验证亲脂性的辛伐他汀能否减弱人静息状态下的交感神经兴奋,增强MSNA和心率的压力感受反射调节、血流介导的血管舒张功能和胰岛素敏感性。方法:进行前瞻性、随机、
Previous findings on patients with hypertension complicated with hypercholesterolemia suggest that statins reduce muscle sympathetic nerve activity (MSNA), but these studies do not analyze potential mechanisms of ganglia sites for this mechanism and the effect on blood vessels Endothelial function or insulin resistance. The aim of this study was to determine if lipophilic simvastatin attenuates sympathetic activation in resting human subjects and enhances baroreflex regulation of MSNA and heart rate, Lead to vasodilation and insulin sensitivity. Methods: A prospective, randomized,