【摘 要】
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Endostatin,a 20 kDa C-terminal fragment of collagen XVⅢ,was first identified as a potent angiogenic inhibitor.The anti-angiogenic function of endostatin has be
【机 构】
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NationalEngineeringLaboratoryforAnti-tumorProtein Therapeutics, Beijing 100084, China“,” Beijing Key
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Endostatin,a 20 kDa C-terminal fragment of collagen XVⅢ,was first identified as a potent angiogenic inhibitor.The anti-angiogenic function of endostatin has been well documented during the past decade.Recently,several studies demonstrated that endostatin also inhibits tumor lymphangiogenesis and lymphatic metastasis.However,the exact mechanism that endostatin executes its anti-angiogenic and anti-lymphangiogenic functions remains elusive.In the current mini-review,we briefly summarize recent novel findings,including the functions of endostatin targeting not only angiogenesis but also lymphangiogenesis,and the underlying mechanism by which endostatin intealization regulates its biological functions.
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