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Objective:To investigated whether erythropoietin(EPO)would promote the proliferation of human caner cell line MCF-7,Panc-1 and HepG2 so as to determine whether EPO would result a worse prognosis to the patients with malignant diseases.Methods:We examined the growth inhibitory or promotional effect of EPO to MCF-7,Panc-1 and HepG2 by MTI assay.Then we examined lhe cell cycle of those cancer cell lines which was cultured with EPO and without EPO by FCM.Results:The results showed there was no significant growth inhibitory or promotional etfect of EPO to MCF-7,Panc-1 and HepG2.The cell cycle of those cancer cell lines cultured with EPO also has no significant different to that of those cancer cell lines cultured without EPO.Conclusion:It is concluded that EPO has no promotion effect to the caner cell linesproliferation,and maybe will not result a worse prognosis to the patients with malignant diseases.