论文部分内容阅读
采用甲氧补骨脂和长波紫外线的光化学疗法(简称PUVA)治疗蕈样肉芽肿曾有报道,但通过临床和病理来判断治疗效果的例子还较少,作者报道6例均通过临床和组织病理的评定。治疗方法:内服甲氧补骨脂30～50毫克,剂量按体重而不同,服药2小时后用高强度长波紫外线照射,每周3次,照射量逐渐增加,疗程为2～6周。治疗前后均作了病理检查。临床分期:蕈样肉芽肿的分期是根据皮肤、淋巴结、肝及脾的临床检查。0期——血管性萎缩性皮肤异色症;Ⅰ期——斑块状损害;Ⅱ期——浸润性斑块;Ⅲ期——结节性肿瘤;Ⅳ期——淋巴结组织学改变。Ⅴ期——肝脾病变。组织病理检查:“蕈样肉芽肿细胞”(简称MF细胞)为非典型的淋巴样细胞,有大而深染的核。表皮
Photochemical therapy (PUVA) using methoxy psoriasis and long-wave ultraviolet light has been reported for the treatment of mycosis fungoides, but there are few examples of clinical and pathological judgments of therapeutic effects. The authors reported that 6 cases all passed clinical and histopathology. The assessment. Treatment: Oral administration of methoxy psoriasis 30 ~ 50 mg, the dose varies according to body weight, after 2 hours of medication with high-intensity ultraviolet radiation, 3 times a week, the amount of radiation gradually increased, the course of treatment is 2 to 6 weeks. Pathological examinations were performed before and after treatment. Clinical stage: The stage of mycosis fungoides is based on clinical examination of skin, lymph nodes, liver, and spleen. Stage 0 - Vascular atrophy of skin heterochromatic disease; Stage I - plaque-like lesions; Stage II - infiltrating plaques; Stage III - nodular tumors; Stage IV - histological changes of lymph nodes. V period - liver and spleen lesions. Histopathological examination: “mycosis granulosa cells” (referred to as MF cells) are atypical lymphoid cells with large, darkly stained nuclei. epidermis