耐药性指病原微生物、某些原虫以及肿瘤细胞等对药物产生的耐受现象,也称抗药性。(1)病原微生物的耐药性。根据耐药性产生的生化机理,临床上应注意合理使用抗菌药物。一是凡属可用可不用者尽量不用,一种抗菌药物能奏效时不同时使用两种抗菌药物,不滥作预防用药和局部用药,药量要足够,疗程要恰当,一般还应避免长期用药,对于耐药菌株感染时应改用细菌敏感的抗生素或采用联合用药;二是有计划地将抗菌药物分期分批交换使用,以减少耐药菌株产生。(2)某些原虫的耐药性。恶性疟原虫对氯喹的耐 Resistance refers to the pathogenic microorganisms, some protozoa and tumor cells on the phenomenon of drug resistance, also known as drug resistance. (1) pathogenic microbial resistance. According to the biochemical mechanism of drug resistance, clinical rational use of antimicrobial drugs should be noted. First, those who are available may not be as far as possible without an antibacterial drug can not be effective at the same time the use of two antimicrobial drugs, do not abuse preventive medicine and local drug use, dosage should be adequate, the course should be appropriate, generally should also avoid long-term medication , For resistant strains of infection should be replaced by bacteria-sensitive antibiotics or combination therapy; the second is the planned use of antibacterials in batches swap to reduce the generation of drug-resistant strains. (2) resistance of some protozoa. Plasmodium falciparum resistance to chloroquine