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目的 探讨不同剂量双复磷加阿托品联合呼吸机治疗氧乐果中毒所致呼吸肌麻痹的疗效。方法 实验大鼠均给予 2倍LD50 剂量的氧乐果染毒 ,以 10mg/kg的阿托品对抗胆碱能症状。当大鼠呼吸频率减慢、呼吸困难时即行气管插管并辅助机械通气 ,阿托品 +呼吸机治疗组阿托品继续原剂量治疗 ,阿托品 +呼吸机 +双复磷 8、15、2 0mg/kg组于呼吸机治疗即刻及治疗后 1、2、3h肌内注射双复磷 ,阿托品减至首剂量的 1/3～ 2 /3,以维持阿托品化为度。经联合治疗后 1、2、3h试行脱机 ,若大鼠在上述时间中任何一次脱机超过 6 0min ,则为联合治疗成功。一次脱机后大鼠存活超过 6 0min或第 3次脱机后迅速死亡 ,均取游离膈神经膈肌标本经MS 30 2生理药理分析仪测定膈肌功能。结果阿托品 +呼吸机治疗组大鼠膈肌功能恢复不佳 ,无一只大鼠脱机成功 ;阿托品 +呼吸机 +双复磷 8、15、2 0mg/kg组大鼠膈肌功能均恢复良好 ,3h脱机成功率均在 80 %以上 ,与阿托品 +呼吸机治疗组比较 ,差异均有显著性 (P <0 .0 1)。外加乙酰胆碱 (ACh)后 ,阿托品 +呼吸机 +双复磷 8、15、2 0mg/kg组大鼠膈肌功能均随加ACH后的时间延长而逐渐下降。结论 适量双复磷联合阿托品并辅助呼吸机治疗氧乐果中毒所致的呼吸肌麻痹 ,能加速中毒大鼠膈肌功能恢复 ,降?
Objective To investigate the efficacy of different doses of bisphosphorus plus atropine combined with ventilator in the treatment of respiratory muscle paralysis caused by omethoate poisoning. Methods Experimental rats were given twice the dose of LD50 omethoate, with 10mg / kg of atropine on the symptoms of cholinergic. When the respiratory rate of rats slowed down, breathing difficulties when the endotracheal intubation and assisted mechanical ventilation, atropine + ventilator treatment group atropine continue the original dose of treatment, atropine + ventilator + bisphosphonates 8,15,2 0 mg / kg group at Ventilator immediately and after treatment 1, 2, 3h intramuscular injection of bisphosphorus, atropine reduced to the first dose of 1/3 ~ 2/3, in order to maintain the degree of atropine. 1, 2, 3h after the joint treatment of off-line test, if the rats in any of the above time off more than 60min, the successful combination therapy. After an off-line survival of rats more than 60min or the third after the death of the rapid death, were taken from the phrenic diaphragmatic muscle samples were measured by MS302 physiological and pharmacological analyzer diaphragm function. Results Atropine + ventilator treatment group rats with poor recovery of diaphragm function, none of the rats off-line success; atropine + ventilator + metoprolol 8,15,2 0mg / kg group rats diaphragm function recovered well, 3h Offline success rates were above 80%, compared with atropine + ventilator treatment group, the difference was significant (P <0.01). After addition of ACh, the function of diaphragmatic muscle of rats in atropine + ventilator + bispyriboyl 8, 15, and 20 mg / kg groups decreased gradually with the prolongation of ACH. Conclusion Appropriate amount of BDP combined with atropine and assisted ventilator in the treatment of respiratory muscle paralysis caused by omethoate can accelerate the functional recovery of diaphragmatic muscle in rats,