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目的:探讨Tei指数在评价肺动脉高压(PH)患者右心室功能中的价值及其影响因素。方法:测量45例PH患者[25例肺源性PH患者,20例为继发于房间隔缺损(ASD)的PH患者]和26例正常对照组的右心常规超声指标,分别测量相关时间间期并计算右室Tei指数。结果:(1)病例组Tei指数明显增高,与对照组相比差异有统计学意义(P<0.01);(2)对照组右室Tei指数与年龄呈正相关(r=0.4,P<0.01),各病例组右室Tei指数与年龄间无相关性;(3)对照组及各病例组右室Tei指数均与心率、右室舒张末期前后径无相关性;(4)肺源性PH组右室Tei指数与肺动脉收缩压(SPAP)无相关性,ASD性PH患者Tei指数与SPAP存在相关关系(r=0.48,P<0.05)。结论:(1)Tei指数是评价PH患者右室功能简便而准确的敏感指标;(2)右心室功能受损状态受压力负荷增加影响大,受容量负荷增加影响小,但就非高动力性PH患者而言,其右室功能受损程度并不与SPAP升高程度呈相关关系。
Objective: To investigate the value of Tei index in assessing right ventricular function in patients with pulmonary hypertension (PH) and its influencing factors. Methods: Routine right heart ultrasound was performed in 45 patients with PH (25 PH patients with PH and 20 patients with atrial septal defect (ASD) secondary to ASD) and 26 healthy controls. The relative time Period and calculate the right ventricular Tei index. Results: (1) The Tei index of cases was significantly higher than that of control group (P <0.01); (2) Tei index of right ventricle was positively correlated with age (r = 0.4, P <0.01) (3) The Tei index of right ventricle in control group and each case group had no correlation with heart rate and right ventricular end-diastolic anteroposterior diameter; (4) Pulmonary PH group There was no correlation between Tei index of right ventricle and pulmonary artery systolic pressure (SPAP). There was a correlation between Tei index and SPAP in ASD PH patients (r = 0.48, P <0.05). Conclusions: (1) Tei index is a simple and accurate sensitive index to evaluate the right ventricular function in patients with PH. (2) Impaired right ventricular function is greatly affected by the increase of pressure load and less affected by the increase of capacity load. However, In patients with PH, the extent of impaired right ventricular function does not correlate with the level of SPAP.