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为了探讨早期微量喂养提高新生儿耐受和降低胆汁淤积的效果研究,选取2012年2月至2014年2月来我院进行抢救的出现急性呼吸衰竭患儿120例,按照随机数字表法将其分为A组和B组。给予A组患儿全静脉营养,给予B组患儿早期微量喂养,对比治疗期间两组患儿耐受情况和出现不良反应情况;记录两组患儿体重恢复所需时间、进行机械通气的总时间、患儿达到全量胃肠营养的总时间和住院时长;比较两组患儿出现胆汁淤积例数;对比干预前后患儿血清总胆红素、血清总胆汁酸和结合胆红素水平。研究显示,B组患儿耐受人数显著高于A组患儿(p<0.05);B组患儿胃肠功能紊乱与坏死性小肠结肠炎数量明显低于A组患儿(p<0.05);B组患儿达全量胃肠营养总时长和住院时长都明显短于A组患儿(p<0.05)。B组患儿出现胆汁淤积例数显著少于A组患儿(p<0.05)。治疗后B组患儿TBIL、DBIL、TBA水平均显著低于A组患儿(p<0.05)。因此,对进行机械通气的新生儿采用早期微量喂养,有利于提高患儿治疗耐受性,减少并发症的发生,缩短患儿住院时长,值得临床推广。
In order to explore the effect of early micronutrient feeding to improve neonatal tolerance and reduce cholestasis, we selected 120 children with acute respiratory failure who came to our hospital from February 2012 to February 2014 to conduct random number table Divided into A group and B group. All patients in group A were given intravenous nutrition and group B was given early micronutrient feeding. The tolerability and adverse reactions of two groups of children were compared during treatment. The time needed for recovery of body weight in both groups was recorded, and the total mechanical ventilation Time, the total time of gastrointestinal nutrition and the length of hospital stay of children. The cholestasis cases were compared between the two groups. The serum total bilirubin, serum total bile acid and conjugated bilirubin were compared before and after intervention. The study showed that the number of patients tolerated in group B was significantly higher than that in group A (p <0.05). The number of gastrointestinal disorders and necrotizing enterocolitis in group B was significantly lower than that of group A (p <0.05) The total amount of gastrointestinal nutrition and length of hospital stay in group B were significantly shorter than those in group A (p <0.05). There were significantly fewer cases of cholestasis in group B than in group A (p <0.05). After treatment, the levels of TBIL, DBIL and TBA in group B were significantly lower than those in group A (p <0.05). Therefore, the use of early micro-feeding of neonates with mechanical ventilation will help to improve the treatment tolerance of patients, reduce the incidence of complications and shorten the length of hospital stay, which is worthy of clinical promotion.