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茶碱和甲氢泼尼松琥珀酸钠(Solu-Medrol)常合并用于治疗严重的支气管哮喘和由毛细支气管水肿引起的慢性阻塞性肺病。以往,用于静脉给药的茶碱制剂,仅有氨茶碱注射液。现已有标准浓度的茶碱注射液商品供应[用5%葡萄糖注射液(D5W)稀释茶碱而成]。以茶碱代替氨茶碱静脉给药可避免氨茶碱制剂中乙二胺引起的过敏反应,并可简化根据茶碱血清浓度数据来调整静脉给药量的方法。但茶碱与 Solu—Medrol 配伍性方面的报道很少,为此,作者对茶碱在D5W 中和 Solu—Medrol 在临床常用浓度范围内合
Theophylline and sodium methylprednisolone (Solu-Medrol) are often combined for the treatment of severe bronchial asthma and chronic obstructive pulmonary disease caused by capillary bronchial edema. In the past, theophylline formulation for intravenous administration, only aminophylline injection. Now available in standard concentrations of theophylline injection product supply [with 5% glucose injection (D5W) diluted theophylline]. Intravenous theophylline instead of aminophylline can avoid the allergic reaction caused by ethylenediamine in the aminophylline preparation and can simplify the method of adjusting the intravenous dosage according to theophylline serum concentration data. However, the theophylline and Solu-Medrol compatibility rarely reported, for this reason, the authors of theophylline in D5W and Solu-Medrol in the clinical concentration range