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B-1a细胞的表面特征是CD11b~+CD5~+IgM~+,其表达的CD5分子对BCR的传导有抑制作用。B-1a细胞在自身免疫性疾病中数量增多,并可能是抗红细胞自身抗体的来源;IL-10主要由B-1a细胞分泌,并对B-1a细胞的生长发育起重要作用,IL-10能促进抗红细胞自身抗体的分泌。
The surface features of B-1a cells are CD11b ~ + CD5 ~ + IgM ~ +, and the expression of CD5 molecules can inhibit the BCR transduction. IL-10 is mainly secreted by B-1a cells and plays an important role in the growth and development of B-1a cells. The expression of IL-10 Can promote anti-red blood cell autoantibody secretion.