【摘 要】
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BACKGROUND AND OBJECTIVESome antiepileptic drugs (AEDs) have been shown to interfere with normal brain development early in life. In addition it is well recognized that many AEDs can adversely affect
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BACKGROUND AND OBJECTIVESome antiepileptic drugs (AEDs) have been shown to interfere with normal brain development early in life. In addition it is well recognized that many AEDs can adversely affect cognition. This study investigated the effect of drug withdrawal on intelligence after epilepsy surgery.
METHODSThe Time to Stop (TTS) study, a retrospective, European, multicentre, cohort study, collected data regarding AED withdrawal as related to seizure outcome. Subjects were patients younger than 18 years of age at the time of surgery, who began AED reduction postoperatively, all with at least one year of postoperative follow-up. All participants had undergone pre-and at least one post-operative neuropsychological assessment. Analyzed were the association between AED withdrawal, IQ and delta IQ.
RESULTSThe mean age at surgery was 9.6 years, with a mean of 19.8 months between surgery and the latest neuropsychological assessment. The mean IQ change for all patients who reduced or stopped AEDs was 4.6 points, while that for those who achieved complete withdrawal was 5.6. A significant relationship was found between the number of AEDs reduced and a greater gain in IQ (P<0.001).
CONCLUSIONThis study of children undergoing epilepsy surgery found that withdrawal of antiepileptic drugs is independently associated with improvement in intelligence quotient.
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