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99只新生大鼠缺氧缺血性脑病模型随机分为三组。预防组和治疗组分别于缺氧缺血前、后给予氟桂嗪，观察各组模型的行为改变、脑含水量、脑大体和显微镜下改变。预防组脑含水量88．34±1．12％，明显低于对照组的90．38±2．24％（P＜0．005），脑大体改变和显微镜下改变也比对照组明显减轻（P＜0．001和P＜0．01）。治疗组各项检查虽有减轻，却无显著性差异（P＞0．05）。本实验表明氟桂嗪能减轻新生大鼠缺氧缺血性脑损伤。
Totally 99 neonatal rats with hypoxic-ischemic encephalopathy were randomly divided into three groups. Preventive and therapeutic groups were given before and after hypoxia and ischemia flunarizine, behavioral changes observed in each model, brain water content, brain and microscopic changes. The brain water content in the prevention group was 88.34 ± 1.12%, which was significantly lower than that in the control group (90.38 ± 2.24%, P <0.005). The changes in the general brain and the microscope were also significantly less than those in the control group P <0.001 and P <0.01). Although the treatment group to reduce the various tests, but no significant difference (P> 0.05). This experiment shows that flunarizine can reduce neonatal hypoxic-ischemic brain damage.