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目的通过比较天花粉蛋白宫颈注射和肌肉注射的疗效和副反应 ,探讨宫颈注射天花粉蛋白治疗输卵管妊娠的临床价值。 方法对输卵管妊娠患者 1 8例行天花粉蛋白宫颈注射和 2 0例行肌肉注射 ,通过 2～ 3d复查尿hCG定量、B超监测盆腔包块大小变化 ,了解临床疗效。通过用药后患者头痛、咽痛、四肢酸痛及发热发生率和程度评价两种用药方法的副反应发生和严重程度。 结果两组患者年龄和一般资料无显著性差异 ,肌肉注射组和宫颈注射组治愈率分别达 90 %与 94% ,无显著性差异。宫颈注射组的副反应轻于肌肉注射组 ,尤其在体温升高及持续时间上 ,有显著性差异 (P <0 .0 5 )。 结论天花粉蛋白治疗输卵管妊娠总有效率达 92 % ,宫颈注射与肌肉注射效果相似 ,而全身副反应前者显著较轻。
Objective To compare the curative effect and adverse reactions of trichosanthin into cervical injection and intramuscular injection, and to explore the clinical value of cervical injection of trichosanthin in the treatment of tubal pregnancy. Methods 18 cases of tubal pregnancy patients with trichosanthin injection and 20 intramuscular injection of urine, 2 ~ 3d urine urinary hCG quantitative, B-ultrasound monitoring of pelvic mass size changes, to understand the clinical efficacy. The incidence and severity of side effects of the two treatment methods were evaluated by the incidence and extent of headache, sore throat, limb pain, and fever in the patients after treatment. Results There was no significant difference in age and general data between the two groups. The cure rates of intramuscular injection group and cervical injection group were 90% and 94% respectively, with no significant difference. Cervical injection group had less side effects than intramuscular injection group, especially in the body temperature rise and duration, there was a significant difference (P <0.05). Conclusion Trichosanthin treatment of tubal pregnancy, the total effective rate of 92%, cervical injection and intramuscular injection of similar effects, while the former was significantly less systemic side effects.