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目的:通过联合检测血浆B钠尿肽(BNP)、C反应蛋白(CRP)和血小板(PLT)水平与心功能的分级(NYHA)之间的关系,进行三者与充血性心力衰竭(CHF)患者的相关性研究。方法:选取CHF患者86例为一组,分别动态监测其血浆BNP、CRP及PLT水平,并选52名健康志愿者为对照组。结果:慢性充血性心衰患者血浆BNP、CRP与对照组比较差别有统计学意义(P<0.01),慢性充血性心衰患者的血小板(PLT)计数与对照组比较差别无统计学意义(P>0.05),慢性充血性心衰患者血小板体积分布宽度(PDW)与对照组比较差别有统计学意义(P<0.05),慢性心衰患者平均血小板体积(MPV)与对照组比较差别有统计学意义(P<0.01)。BNP、CRP与CHF严重程度有关(P<0.01,P<0.05)。结论:血浆BNP、CRP、PDW、MPV在CHF患者中明显升高,且升高幅度与病情的严重性相一致,对疗效观察和病情转归的判断有一定的临床价值。
OBJECTIVE: To investigate the relationship between plasma B-natriuretic peptide (BNP), C-reactive protein (CRP) and platelet (PLT) levels and NYHA classification in patients with congestive heart failure (CHF) Patient correlation studies. Methods: A total of 86 CHF patients were enrolled in this study. Plasma BNP, CRP and PLT levels were dynamically monitored. 52 healthy volunteers were selected as control group. Results: The plasma levels of BNP and CRP in patients with chronic congestive heart failure were significantly different from those in the control group (P <0.01). There was no significant difference in the platelet count (PLT) between the patients with chronic congestive heart failure and the control group (P > 0.05). The platelet volume distribution width (PDW) in patients with chronic congestive heart failure was significantly lower than that in the control group (P <0.05). The mean platelet volume (MPV) in patients with chronic heart failure was significantly lower than that in the control group Significance (P <0.01). BNP and CRP were related to the severity of CHF (P <0.01, P <0.05). CONCLUSION: Plasma BNP, CRP, PDW and MPV are significantly elevated in patients with CHF, and the magnitude of the increase is consistent with the severity of the disease. Therefore, it is of clinical significance to observe the curative effect and prognosis of CHF.