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目的观察中药对小儿复发性呼吸道乳头状瘤(JORRP)中人乳头状瘤病毒(HPV)含量的影响。方法将80例JORRP患者分为治疗组40例、对照组40例。对照组采用全麻支撑喉镜下CO2激光手术治疗,术中彻底切除肿瘤组织。治疗组在与对照组相同手术治疗的基础上,根据患儿Derkay评分加服中药基本方Ⅰ或基本方Ⅱ治疗。比较2组治疗前后的HPV-DNA含量。结果HPV-DNA含量,治疗前治疗组与对照组比较差异无统计学意义(P>0.05);治疗后治疗组较本组治疗前降低,差异有统计学意义(P<0.05);对照组治疗前后比较差异无统计学意义(P>0.05);治疗后治疗组HPV-DNA含量明显低于对照组,2组比较差异有统计学意义(P<0.05)。结论中药可使JORRP中HPV含量降低。
Objective To observe the effect of traditional Chinese medicine on human papillomavirus (HPV) in children with recurrent respiratory papilloma (JORRP). Methods Eighty patients with JORRP were divided into treatment group (40 cases) and control group (40 cases). Control group under general anesthesia with laryngoscope CO2 laser surgery, complete removal of tumor tissue during surgery. On the basis of the same surgical treatment as the control group, the treatment group was given basic Chinese medicine Ⅰ or basic Ⅱ according to the Derkay score of the children. The levels of HPV-DNA in two groups before and after treatment were compared. Results There was no significant difference in the content of HPV-DNA between the treatment group and the control group before treatment (P> 0.05), and the difference was statistically significant (P <0.05) between the treatment group and the control group before treatment There was no significant difference between before and after treatment (P> 0.05). After treatment, the content of HPV-DNA in the treatment group was significantly lower than that in the control group. There was significant difference between the two groups (P <0.05). Conclusion Chinese medicine can reduce the HPV content in JORRP.