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目的探讨宁夏回族、汉族血管紧张素转换酶(ACE)基因I/D多态性与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压的关联性。方法入选宁夏回族OSAHS患者112例、汉族OSAHS患者157例,根据是否合并高血压分为2组,即单纯OSAHS组、OSAHS合并高血压组;选同期无基础疾病的回族60例、汉族92例为健康对照组。应用聚合酶链反应(PCR)检测ACE基因I/D多态性。结果回族、汉族间进行比较,对照组、单纯OSAHS组、OSAHS合并高血压组其Ⅱ基因型频率、Ⅰ等位基因频率差异均无统计学意义(P>0.05)。回族单纯OSAHS组、OSAHS合并高血压组Ⅱ基因型频率及Ⅰ等位基因频率高于回族对照组(P<0.05);汉族单纯OSAHS组、OSAHS合并高血压组Ⅱ基因型频率及Ⅰ等位基因频率高于汉族对照组(P<0.05)。回族、汉族单纯OSASH组与OSASH合并高血压组同民族间进行比较,Ⅱ基因型及Ⅰ等位基因频率差异均无统计学意义(P>0.05)。结论 ACE基因I/D多态性在宁夏回族、汉族人群间分布无显著性差异,ACE基因Ⅱ基因型及Ⅰ等位基因与宁夏回族、汉族OSAHS发病及OSAHS合并高血压存在关联性。
Objective To investigate the association of angiotensin converting enzyme (ACE) gene I / D polymorphism with hypertension and obstructive sleep apnea-hypopnea syndrome (OSAHS) in Hui and Han Chinese in Ningxia. Methods One hundred and twelve patients with OSAHS in Ningxia and 157 OSAHS patients were divided into two groups according to whether they were complicated with hypertension: OSAHS alone and OSAHS with hypertension. Sixty Hui patients without basic diseases during the same period were selected as 92 Han patients Healthy control group. The ACE gene I / D polymorphism was detected by polymerase chain reaction (PCR). Results There was no significant difference in the frequency of genotype Ⅱ and Ⅰ allele between control group, OSAHS group and OSAHS group (P> 0.05). The frequencies of genotype Ⅱ and Ⅰ allele in OSAHS group and OSAHS group were higher than those in Hui control group (P <0.05). The frequencies of genotype Ⅱ and Ⅰ allele in OSAHS group and OSAHS group The frequency was higher than that of Han control group (P <0.05). There were no significant differences in genotype Ⅱ and Ⅰ allele frequency between the OSAS group and the OSASH hypertension group (P> 0.05). Conclusions There is no significant difference in ACE gene I / D polymorphism among Hui and Han populations in Ningxia. There is a correlation between genotype Ⅱ and Ⅰ allele of ACE gene and OSAHS in Ningxia and Han and OSAHS with hypertension.