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To check the dose uniformity and to determine the efficiency of medical devices sterilization by gamma irradiation after three half lives of the source,calculations of the absorbed dose were carried out.Monte Carlo simulations and dosimetry measurements,were established to study the radiation processing quality control.An isodose chart was created by GEANT4 Monte Carlo code to evaluate the absorbed dose rate uniformity inside the irradiation room from the year of the installation until the year of the source reload.The dose uniformity ratio (DUR) is deduced from maximum and minimum experimental doses in medical devices after three half lives of the source.