临床上由于创伤、肿瘤、感染等引起的组织缺损常需皮瓣修复,虽然皮瓣外科技术过去几十年中已获得巨大发展,但皮瓣手术仍面临坏死的风险。某些类型皮瓣的部分坏死率或脂肪液化率可达30%,究其原因,主要由缺血再灌注损伤引起。因此,缺血再灌注损伤对于整个皮瓣的存活起着决定性的作用。大量研究资料表明缺血再灌注损伤是多细胞参与、多因子介导的一系列复杂病理生理过程,根据对已知缺血再 Flap repair is often required for tissue defects clinically due to trauma, tumors, infections, etc. Although flap surgery has gained tremendous growth over the past few decades, there is still a risk of necrosis of the flap surgery. Some types of flap partial necrosis or fat liquefaction rate of up to 30%, the reason, mainly caused by ischemia-reperfusion injury. Therefore, ischemia-reperfusion injury plays a decisive role in the survival of the entire flap. A large number of research data show that ischemia-reperfusion injury is a multi-cellular involvement, multi-factor mediated a series of complex pathophysiological processes, according to the known ischemia again