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目的探讨血浆D-二聚体、纤维蛋白原及活化部分凝血活酶时间对缺血性结肠诊断的应用价值。方法回顾性分析30例缺血性结肠炎住院患者及30例健康对照,比较两组的血浆D-二聚体水平及部分患者、健康者的纤维蛋白原定量及活化部分凝血活酶时间。结果缺血性肠炎组D-二聚体[(0.49±0.59)mg/L]高于对照组[(0.06±0.05)mg/L](P<0.01)。采用ROC曲线分析,它对缺血性肠炎检测的敏感性为86.7%,特异性为90.0%。缺血性肠炎患者血浆纤维蛋白原定量[(3.39±0.92)g/L]高于对照组[(2.72±0.39)g/L](P<0.05),但敏感性仅为55.6%,特异性为90.9%。缺血性肠炎组活化部分凝血活酶时间[(31.35±5.07)秒]与对照组[(33.24±3.02)秒]比较无差异显著性(P>0.05)。结论血浆D-二聚体的检测可为缺血性结肠炎的诊断提供帮助;血浆纤维蛋白原因敏感性低使其临床应用受限;活化部分凝血活酶时间对缺血性结肠炎诊断无意义。
Objective To investigate the value of plasma D-dimer, fibrinogen and activated partial thromboplastin time in the diagnosis of ischemic colon. Methods Thirty patients with ischemic colitis and 30 healthy controls were retrospectively analyzed. Plasma D-dimer levels and fibrinogen quantitation and activated partial thromboplastin time in healthy subjects were compared between the two groups. Results D-dimer [(0.49 ± 0.59) mg / L] in ischemic enteritis group was significantly higher than that in control group [(0.06 ± 0.05) mg / L] (P <0.01). Using ROC curve analysis, it has a sensitivity of 86.7% and a specificity of 90.0% for the detection of ischemic enteritis. The level of plasma fibrinogen in patients with ischemic enteritis [(3.39 ± 0.92) g / L] was significantly higher than that in the control group (2.72 ± 0.39 g / L) (P <0.05), but the sensitivity was only 55.6% 90.9%. Compared with the control group [(33.24 ± 3.02) s], the partial thromboplastin time of ischemic enteritis group was no significant difference (P> 0.05). Conclusion The detection of plasma D-dimer may be helpful in the diagnosis of ischemic colitis. The low sensitivity of plasma fibrin causes limited clinical application. The activation of partial thromboplastin time is not meaningful for the diagnosis of ischemic colitis .