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目的 探讨虚汗停颗粒对实验性小鼠免疫器官重量的影响。方法 取小鼠 5 7只 ,随机分成 5组 ,即生理盐水组 (11只 )、环磷酰胺组 (13只 )、女贞子组 (11只 )、虚汗停 1组 (11只 )、虚汗停 2组 (各 11只 )。除生理盐水外 ,其余各组于第 4天腹腔注射环磷酰胺 6 0mg·kg- 1 一次 ,制作免疫器官减重模型。生理盐水组和环磷酰胺组每天腹腔注射生理盐水 0 .5ml,其它各组分别给予女贞子煎剂 2 5g/kg体重、虚汗停 4g/kg体重和 8g kg体重。灌胃给药 7天 ,于末次给药后 2 4小时 ,摘眼球放血处死 ,称体重 ,取出胸腺及脾脏称重 ,以胸腺重量或脾脏重量 (mg)与体重 (g)之比作为胸腺重或脾重。结果 生理盐水组小鼠胸腺重和脾重都大于模型组 ,差异有极显著性意义 (P <0 .0 0 1) ;女贞子组和虚汗停组小鼠胸腺重和脾重大于模型组 ,差异有显著性意义 (P <0 .0 1,0 .0 1,0 .0 5 ) 。结论 虚汗停颗粒可提高试验小鼠的胸腺重和脾重 ,提示虚汗停颗粒可增强小鼠的非特异性免疫功能。
Objective To investigate the effect of imaginary granules on the weight of experimental immune organs in mice. Methods A total of 57 mice were randomly divided into five groups: saline group (11), cyclophosphamide group (13), Ligustrum lucidum (11), imaginary stop 1 group (11), sweating Stop 2 groups (11 each). Except for normal saline, the other groups were injected with cyclophosphamide 60 mg·kg -1 intraperitoneally on the 4th day to make a weight loss model of immune organs. The normal saline group and the cyclophosphamide group were intraperitoneally injected with 0.5 ml normal saline, and other groups were given Ligustrum lucidum decoction 25 g/kg body weight, imaginary sweating 4 g/kg body weight, and 8 g kg body weight. After intragastric administration for 7 days, 24 hours after the last administration, the eyeball was excised and sacrificed. The body weight was weighed. The thymus and spleen were removed and weighed. The ratio of thymus weight or spleen weight (mg) to body weight (g) was taken as thymus weight. Or spleen weight. Results The thymus weight and spleen weight of mice in saline group were all greater than those in the model group (P < 0.01). The thymus weight and spleen weight in the Ligustrum lucidum group and the imaginary sweating group were significant in the model group. The difference was significant (P < 0.01, 0.10, 0.55). Conclusion Aspergillus japonicus granules can increase the thymus weight and spleen weight of the experimental mice, suggesting that imaginary perspiration granules can enhance the non-specific immune function of mice.