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rT_3(即reverseT_3,反T_3)是3,3′,5′-三碘甲腺原氨酸的简称,是存在于血清和甲状腺组织中的一种无激素活性的碘化甲腺氨酸.血清中的rT_3主要来自甲状腺素(T_4)的外周代谢,仅少量由甲状腺分泌产生.T_4在外周组织中经脱碘作用转变成活性很强的3,5,3′-三碘甲腺氨酸(T_3)和无活性的rT_3,这可能是机体通过甲状腺外组织调节甲状腺功能的一种生理机制.1956年Roche等发现大鼠甲状腺及血浆存在有rT_3.Chopra在1974年证实了rT_3是人血清和甲状腺球蛋白中的一种正常组分.其后,人们对rT_3进行了广泛的研究,对甲状腺激素的代谢、rT_3的生理变化及临床意义有了新的认识.目前,血清rT_3浓度的测定已成为研究甲状腺激素代谢和诊断甲状
rT_3 (ie, reverseT_3, anti-T_3) is short for 3,3 ’, 5’-triiodothyronine and is a hormone-inactive thyrotropin that exists in serum and thyroid tissue. Serum In the rT_3 mainly from peripheral metabolism of thyroxine (T_4), only a small amount produced by the thyroid secretion.T4 in the peripheral tissues by deiodination into highly active 3,5,3’-triiodothyronine ( T_3) and inactive rT_3, which may be the body through thyroid tissue regulation of thyroid function in a physiological mechanism.In 1956, Roche and other found thyroid and plasma rat rT_3.Chopra confirmed in 1974 that rT_3 is human serum and Thyroglobulin is a normal component.After that, people conducted extensive research on rT_3, thyroid hormone metabolism, rT_3 physiological changes and clinical significance of a new understanding.At present, the determination of serum rT_3 concentration Become a research thyroid hormone metabolism and diagnosis of thyroid