论文部分内容阅读
目的:探讨高同型半胱氨酸血症(hyper homocysteinemia,Hhcy)与中青年脑梗死的关系。方法:测定80例中青年脑梗死患者血浆同型半胱氨酸,叶酸,VitB12,颈动脉内膜中层厚度,低密度脂蛋白(LDL)等指标,与80例正常对照组比较。结果:①脑梗死组血浆HCY水平、颈动脉内膜中层厚度和LDL等指标明显高于对照组(P<0.01)。叶酸及VitB12水平则低于对照组(P<0.01);②脑梗死组和对照组血浆Hcy水平与血叶酸、VitB12水平、欧洲脑卒中量表评分均呈显著负相关性;③不同类型脑梗死Hcy水平比较差异无显著性。结论:高同型半胱氨酸血症是中青年脑梗死的独立危险因素,导致高同型半胱氨酸血症的原因可能是血浆内叶酸和VitB12的降低。
Objective: To investigate the relationship between hyperhomocysteinemia (Hhcy) and middle-aged and young cerebral infarction. Methods: Plasma homocysteine, folic acid, VitB12, carotid artery intima-media thickness and LDL were measured in 80 middle-aged and young patients with cerebral infarction, compared with 80 normal controls. Results: ①The levels of HCY, carotid artery intima-media thickness and LDL in cerebral infarction group were significantly higher than those in control group (P <0.01). Folic acid and VitB12 levels were lower than those in the control group (P <0.01). ②The levels of plasma Hcy in cerebral infarction group and control group were negatively correlated with the levels of serum folate and VitB12 and the European Stroke Scale score. ③The different types of cerebral infarction Hcy levels were no significant difference. CONCLUSION: Hyperhomocysteinemia is an independent risk factor for middle-aged and young cerebral infarction. The cause of hyperhomocysteinemia may be the decrease of plasma folic acid and VitB12.