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目的探讨肿瘤大小对各T分期胃癌患者预后的影响。方法收集535例行根治术胃癌患者的临床资料,采用ROC曲线下面积取截断点,根据肿瘤直径分为<4.5 cm组和≥4.5 cm组。应用Kaplan-Meier生存曲线比较相同T分期中不同肿瘤大小对胃癌患者预后的影响。结果肿瘤直径<4.5 cm组和≥4.5 cm组患者术后5年累积生存率分别为66.9%和28.3%,其差异有统计学意义(P<0.05)。在T1期患者中,肿瘤直径≥4.5 cm组与<4.5 cm组之间预后差异无统计学意义(P>0.05);在T2及T3期患者中,肿瘤直径≥4.5 cm组和<4.5 cm组之间预后差异有统计学意义(P<0.05);在T4期患者中,肿瘤直径≥4.5 cm组和<4.5 cm组之间预后差异无统计学意义(P>0.05)。结论肿瘤大小是影响T2及T3期胃癌患者预后的重要因素之一。
Objective To investigate the effect of tumor size on the prognosis of patients with T-staged gastric cancer. Methods The clinical data of 535 patients undergoing radical operation for gastric cancer were collected. The area under the ROC curve was taken as cut-off point and divided into groups of <4.5 cm and ≥4.5 cm according to tumor diameter. The Kaplan-Meier survival curves were used to compare the prognosis of gastric cancer patients with different tumor sizes in the same T stage. Results The 5-year cumulative survival rates of patients with tumor diameter <4.5 cm and ≥ 4.5 cm were 66.9% and 28.3%, respectively, with significant difference (P <0.05). There was no significant difference in the prognosis of patients with T1≥4.5 cm and <4.5 cm (P> 0.05). In patients with T2 and T3 tumors, the tumor diameter≥4.5 cm and <4.5 cm (P <0.05). There was no significant difference in the prognosis of patients with T4 diameter between 4.5 cm and 4.5 cm (P> 0.05). Conclusion Tumor size is one of the important factors affecting the prognosis of patients with T2 and T3 gastric cancer.