对３０例功能性消化不良（ＦＤ）患者服用西沙必利前后的胃腔内压力、血中胃动素及胃泌素的变化进行检测，并以１１例正常人作对照。结果：①ＦＤ患者胃窦和胃体基础压、胃窦蠕动压及血中胃动素浓度，明显低于正常对照组（Ｐ值分别＜００５，＜００１）；而胃窦蠕动波持续时间、血中胃泌素浓度与正常组无显著差异（Ｐ＞００５）。②服用西沙必利后，ＦＤ患者与正常对照组胃窦和胃体基础压、胃窦蠕动压及血中胃动素浓度，均较服药前明显升高（Ｐ＜００５，Ｐ＜００１）。而胃窦蠕动波持续时间和血中胃泌素浓度，正常组和ＦＤ组服药前后均无显著差异（Ｐ＞００５）。结论：ＦＤ与胃动力障碍有关，西沙必利治疗ＦＤ是合理、有效的 Gastric cavity pressure, blood motilin and gastrin in 30 patients with functional dyspepsia (FD) were measured before and after cisapride, and 11 normal controls were used as controls. Results: (1) The basic pressure of gastric antrum and gastric body, gastric motility and motilin in patients with FD were significantly lower than those in normal controls (P <005 and <001, respectively) Duration, blood gastrin concentration and no significant difference between the normal group (P> 0  05). ② After cisapride treatment, the basic pressure of gastric antrum and gastric body, gastric motility and motilin in FD patients and normal control group were significantly higher than those before medication (P <005, P <0 01). However, the duration of gastric peristalsis and the concentration of blood gastrin had no significant difference between the normal group and the FD group before and after treatment (P> 005). Conclusion: FD and gastric motility disorders related to cisapride treatment of FD is reasonable and effective