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在母体血清中,人体绒毛膜促性腺激素(hCG)及其游离β-亚单位是Down综合征筛选的最不可区别的标志。本文研究的目的是为了调查在正常妊娠及胎儿为Down综合征的妊娠中有缺口的游离β-亚单位的水平。 选取64例13～18孕周的单胎妊娠胎儿染色体核型正常的孕妇和6例胎儿为Down综合征的孕妇于羊膜腔穿刺前抽取血清样本。对β-亚单位hCG采用2种酶免疫测量法来测定在第43～48碱基对间有肽链缺口的游离β-亚单位hCG的水平。(1)FBT11:用抗
In maternal serum, human chorionic gonadotropin (hCG) and its free beta-subunit are the most distinguishable markers of Down syndrome screening. The purpose of this study was to investigate the level of gapped free beta-subunit in pregnancies of normal pregnancy and fetal Down syndrome. Sixty-four pregnant women with normal fetal karyotype of one fetus with gestational age of 13-18 gestational weeks and 6 pregnant women with Down syndrome were selected before amniocentesis. Two enzyme immunoassays were performed on the [beta] -subunit hCG to determine the level of free [beta] -subunit hCG with peptide chain gaps between the 43-48 base pairs. (1) FBT11: anti-use