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以三唑磷为模式农药,研究了一种外观为颗粒状、用水稀释后成微乳液的农药新剂型——微乳粒剂配制的可行性。以乳状液的中位径(D50)为因变量,各表面活性剂用量为自变量,采用混料均匀试验设计并结合偏最小二乘回归法筛选表面活性剂品种;用比例法与对分法优化各表面活性剂用量;采用旋转挤压造粒法造粒。将筛选获得的农乳500与农乳602号用于配制15%三唑磷微乳粒剂,其乳状液外观为淡蓝色透明状,分散相颗粒迁移速度为0,且不同水质(水硬度:0～3 420 mg/L,水温:10～50℃)下乳液稳定性均合格;乳状液D50为54.2 nm,粒径分布范围为15.7～122 nm,粒径增大速率为0.01%/min;乳状液在相对离心力10 730×g下离心5 min未发生相分离。结果表明:该三唑磷微乳粒剂的乳状液为微乳液,微乳粒剂可以成功配制。
Taking triazophos as model pesticide, the feasibility of preparing a new pesticide formulation - microemulsion formulation with the appearance of granular and diluted with water as microemulsion was studied. The median diameter of emulsion (D50) as the dependent variable, the amount of each surfactant as an independent variable, using mixed experimental design and combined with partial least squares regression screening of surfactant species; using proportional and dichotomy Optimize the amount of each surfactant; granulation using rotary extrusion granulation. The selected agricultural and agricultural milk No. 500 and No. 602 were used to prepare 15% triazophos microemulsion granules. The appearance of the emulsion was light blue and transparent. The migration speed of the dispersed phase granules was 0, and different water quality (water hardness : 0 ~ 3 420 mg / L, water temperature: 10 ~ 50 ℃). The emulsion D50 was 54.2 nm and the particle size distribution ranged from 15.7 to 122 nm. The rate of particle size increase was 0.01% / min ; No phase separation occurred when the emulsion was centrifuged at 10 730 × g for 5 min under relative centrifugal force. The results show that the emulsion of triazophos microemulsion is a microemulsion, and the microemulsion can be successfully formulated.