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目的 观察健脾益气方治疗慢性溃疡性结肠炎（ＣＵＣ） 的临床疗效及治疗机制．方法 临床ＣＵＣ 病例４２０ 例随机分为３ 组， 分别用健脾灵、ＳＡＳＰ 和补脾益肠丸治疗． 实验观察：用离体器官测定仪测定兔离体肠管的运动功能，用碳末法测定小鼠在体小肠推进功能，用大鼠ＣＵＣ 实验模型检查健脾灵对组织病理学及免疫功能的影响．结果 临床共４２０ 例，健脾灵组、ＳＡＳＰ 组和益肠组治愈率分别为６７－７ ％ ，３０－０ ％ 和４８－３ ％ ，组间治愈率比较有非常显著差异（ Ｐ＜ ０－０１） ，３ 组患者血清抗大肠抗体的转阴率分别为８５－４ ％ ，２５－０ ％ 和６４－５ ％ （ Ｐ＜ ０－０１） ． 药理实验：健脾灵煎剂对家兔空、回肠蠕动频率和幅度有明显抑制作用，并能拮抗乙酰胆碱和氯化钡引起小肠强直性收缩及拮抗肾上腺素引起兔肠管抑制作用；对实验大鼠血清抗大肠抗体和ＩｇＧ 的滴度有明显降低作用，并能增加实验大鼠胸腺、脾脏等免疫器官的重量．结论 健脾灵的疗效明显优于ＳＡＳＰ 和补脾益肠丸，其治疗ＣＵＣ 的机制与增强细胞免疫功能、抑制体液免疫功能和免疫调节作用有关，其缓急止痛作用与直接缓解肠管平滑肌痉挛和对抗乙酰胆碱Ｍ － 受体激动作用有关，其涩肠止泻作用是通过抑
Objective To observe the clinical efficacy and treatment mechanism of Jianpiyiqi recipe in the treatment of chronic ulcerative colitis (CUC). Methods A total of 420 clinical CUC cases were randomly divided into 3 groups. They were treated with Jianpiling, SASP and Bupi Yichang Pill respectively. Experimental observation: The organ function of isolated rabbit intestine was determined by an isolated organ tester. The mice were tested for their propulsion function in the small intestine by carbon-pouring method. The effect of Jianpi Ling on histopathology and immune function was examined by rat CUC experimental model. Results A total of 420 patients were clinically treated. The cure rates of Jianpiling group, SASP group and Yichang group were 67-7 %, 30-0 % and 48-3 %, respectively. There was a significant difference in the cure rate between groups (P<0- 01) The anti-colon antibody negative conversion rates in the 3 groups were 85-4 %, 25-0 % and 64-5 %, respectively (P < 0-01). Pharmacological experiment: Jianpiling Decoction has obvious inhibitory effect on the frequency and amplitude of peristalsis in rabbits, and can antagonize the inhibition of intestinal contraction induced by acetylcholine and strontium chloride in rabbits; Serum anti-colon antibody and IgG titers were significantly reduced, and can increase the weight of experimental rats thymus, spleen and other immune organs. Conclusion The efficacy of Jianpiling is significantly better than that of SSP and Bupiyichang Pills. Its mechanism of treatment of CUC is related to the enhancement of cellular immune function, inhibition of humoral immune function and immune regulation, its urgency and analgesic effect and direct remission of intestinal smooth muscle spasm and resistance Acetylcholine M-receptor agonism is related to its astringent intestinal diarrhea effect