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目的评价骨瓜提取物治疗活动期类风湿性关节炎的疗效和安全性。方法 79例类风湿性关节炎患者分为对照组37例和观察组42例,两组均给予基础治疗,观察组除基础治疗外加用骨瓜提取物(75mg/d),疗程3周。观察两组治疗后关节疼痛、晨僵时间、疾病活动DAS28评分、ESR、RF、CRP及不良反应。结果骨瓜提取物治疗3周后,观察组晨僵、关节疼痛症状较对照组缓解,观察组ESR较对照组下降,而DAS28评分、RF、CRP两组差异无统计学意义。结论骨瓜提取物对治疗类风湿性关节炎急性症状有一定的疗效,无明显不良反应。
Objective To evaluate the curative effect and safety of bone pumpkin extract in the treatment of active rheumatoid arthritis. Methods A total of 79 patients with rheumatoid arthritis were divided into control group (n = 37) and observation group (n = 42). Both groups were given basic treatment. In addition to basic treatment, the observation group was given Gukua extract (75mg / d) for 3 weeks. The joint pain, morning stiffness, disease activity DAS28 score, ESR, RF, CRP and adverse reactions were observed after treatment. Results After 3 weeks of treatment, the morning stiffness and joint pain symptoms of the observation group were relieved. The ESR of the observation group was lower than that of the control group. There was no significant difference between the two groups in DAS28 score, RF and CRP. Conclusion Clove extract has some curative effect on the treatment of acute symptoms of rheumatoid arthritis without obvious adverse reactions.