论文部分内容阅读
目的探讨GPX1基因Pro200Leu多态性与冠心病的关系。方法采用病例对照研究方法,收集早发冠心病患者375例,迟发冠心病患者519例,对照334人,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)基因分型技术对GPX1基因Pro200Leu多态性进行检测,采用logistic回归计算Pro200Leu多态性与冠心病风险的比值比(OR值)和95%可信区间(CI)。结果与对照组相比,早发冠心病组携带CT+TT基因型的个体比携带CC基因型更容易患冠心病,多因素调整后,OR=1.96(95%CI=1.17-3.31);迟发冠心病组与对照组相比较,多因素调整后则无统计学意义(OR=1.75,95%CI=0.76-4.02)。结论 GPX1基因Pro200Leu多态性T等位基因可能是早发冠心病的一个危险因素。
Objective To investigate the relationship between GPX1 gene Pro200Leu polymorphism and coronary heart disease. Methods A case-control study was conducted in 375 patients with premature coronary heart disease, 519 patients with late-onset coronary heart disease, and 334 controls. PCR-RFLP genotyping The Pro200Leu polymorphism of GPX1 gene was detected. The odds ratio (OR) and 95% confidence interval (CI) of Pro200Leu polymorphism and coronary heart disease risk were calculated by logistic regression. Results Compared with the control group, individuals with CT + TT genotype in premature coronary heart disease group were more likely to have coronary heart disease than those with CC genotype. OR = 1.96 (95% CI = 1.17-3.31) after adjustment for multiple factors; Compared with the control group, coronary heart disease group had no significant difference after adjusting for multiple factors (OR = 1.75, 95% CI = 0.76-4.02). Conclusion The T allele of GPX1 gene Pro200Leu polymorphism may be a risk factor for premature coronary heart disease.