以三氟丙烯基甲醚和正戊酸为原料,合成了三氟丙醛。考察了反应温度、物料配比、催化剂用量及反应时间对三氟丙醛收率的影响。在单因素实验基础上,进行了正交试验,得到了较佳反应条件,温度80℃,正戊酸∶三氟丙烯基甲醚为1.3,催化剂用量2.3%,反应时间9h,此条件下三氟丙醛的收率为91.47%。 Trifluoropropanal was synthesized from trifluoropropenyl methyl ether and n-pentanoic acid. The effects of reaction temperature, material ratio, catalyst amount and reaction time on the yield of trifluoropropanal were investigated. On the basis of single factor experiments, the orthogonal experiment was carried out and the optimum reaction conditions were obtained. The optimum reaction conditions were as follows: temperature 80 ℃, the molar ratio of n-pentanoic acid: trifluoropropenyl methyl ether 1.3, catalyst 2.3%, reaction time 9h, The yield of propanal was 91.47%.