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目的:探究类风湿关节炎(RA)诊断过程中类风湿因子(RF)、抗环瓜氨酸多肽(CCP)抗体和抗角蛋白抗体(AKA)联合检测的应用价值。方法:以我科在2012年9月至2014年3月收治146例类风湿关节炎患者为研究对象,分别对类风湿因子(RF)、抗角蛋白(AKA)抗体、抗环瓜氨酸多肽(CCP)抗体进行检测,然后结合检测结果对类风湿因子(RF)、抗环瓜氨酸多肽(CCP)抗体和抗角蛋白抗体(AKA)在类风湿关节炎中的分布及三者存在的相关性进行分析。结果:类风湿因子(RF)、抗角蛋白抗体(AKA)、抗环瓜氨酸多肽抗体(CCP)两两之间在检查结果没有完全重叠的现象。结论:抗CCP抗体与RF、AKA之间及AKA与RF之间不完全重叠亦无相关性,故联合检测可以提高RA患者诊断率。
Objective: To investigate the value of combination of rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibody and anti-keratin antibody (AKA) in the diagnosis of rheumatoid arthritis (RA). Methods: A total of 146 patients with rheumatoid arthritis were enrolled in our department from September 2012 to March 2014. The effects of rheumatoid factor (RF), anti-keratin (AKA) antibody, anti-cyclic citrullinated peptide (CCP) antibodies were detected in patients with rheumatoid arthritis (RA). The distribution of rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibody and anti-keratin antibody (AKA) Relevance analysis. Results: There was no complete overlap between the results of rheumatoid factor (RF), anti-keratin antibody (AKA) and anti-cyclic citrullinated peptide antibody (CCP). Conclusion: There is no correlation between anti-CCP antibody and RF, AKA and incomplete overlap between AKA and RF. Therefore, joint detection can improve the diagnostic rate of RA patients.