目的观察肺表面活性剂联合持续气道正压通气在新生儿呼吸窘迫综合征中的应用效果。方法选择我院2012年11月至2014年11月收治的80例新生儿呼吸窘迫综合征患儿为研究对象,随机将其分为对照组和观察组,每组各40例,对照组患者给予常规对症支持治疗+持续气道正压通气治疗,观察组患者则在对照组治疗的基础上加用牛肺表面活性剂治疗。比较两组的治疗效果、治疗前后血气指标改善情况、肺部X线改善情况及并发症发生情况。结果观察组治疗总有效率为90.0%,明显高于对照组的75.0%,差异有统计学意义(P<0.05);观察组治疗后的Pa O2明显高于对照组,Pa CO2明显低于对照组,差异均有统计学意义(P<0.05);观察组治疗后肺部X线改善情况显著优于对照组,差异有统计学意义(P<0.05);观察组患儿并发症发生率明显低于对照组,差异有统计学意义(P<0.05)。结论在常规治疗+持续气道正压通气的基础上给予肺表面活性剂治疗新生儿呼吸窘迫综合征,临床效果好,肺血气指标及肺功能改善显著,并发症发生率低,值得临床推广应用。 Objective To observe the effect of pulmonary surfactant combined with continuous positive airway pressure ventilation in neonatal respiratory distress syndrome. Methods Eighty neonates with respiratory distress syndrome admitted from November 2012 to November 2014 in our hospital were randomly divided into control group and observation group with 40 cases in each group and control group Conventional symptomatic supportive therapy + continuous positive airway pressure therapy, the observation group patients in the control group based on the treatment with bovine pulmonary surfactant treatment. The curative effect of the two groups were compared, the improvement of blood gas index before and after treatment, the improvement of pulmonary X-ray and the complication occurred. Results The total effective rate in observation group was 90.0%, which was significantly higher than that in control group (75.0%), the difference was statistically significant (P <0.05); PaO2 in observation group was significantly higher than that in control group, Pa CO2 was significantly lower than that in control group (P <0.05). The improvement of pulmonary X-ray in observation group was significantly better than that in control group (P <0.05). The incidence of complications in observation group was significantly higher than that in control group Lower than the control group, the difference was statistically significant (P <0.05). Conclusions In the treatment of neonatal respiratory distress syndrome on the basis of conventional therapy plus continuous positive airway pressure ventilation, the clinical effect is good, the pulmonary blood gas index and pulmonary function are improved remarkably, and the complication rate is low, which is worthy of clinical application .