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目的探讨胰腺癌根治术后淋巴结总数及阴性淋巴结数与预后的关系。方法回顾性分析山东大学齐鲁医院1998～2007年胰腺癌根治术227例患者的临床资料。探讨淋巴结总数及阴性淋巴结数目与预后的相关性。结果共182例获得随访,随访率为80.2%。无淋巴结转移患者76例,3、5年生存率分别为28.9%、21.0%,淋巴结总数为影响预后的独立因素。有淋巴结转移患者106例,3、5年生存率分别为21.1%、7.5%。淋巴结总数及阴性淋巴结数为影响预后的独立因素。淋巴结总数及阴性淋巴结数具有明显相关性(r=0.919,P<0.05)。结论在根治性手术规范化进行的前提下,可将淋巴结总数及阴性淋巴结数作为胰腺癌患者TNM分期的预后判断辅助指标,使得患者获得更准确的临床分期和预后判断,以期获得最佳远期疗效。
Objective To investigate the relationship between the total number of lymph nodes and the number of negative lymph nodes after radical resection of pancreatic cancer. Methods The clinical data of 227 patients with pancreatic cancer underwent radical resection from 1998 to 2007 in Qilu Hospital of Shandong University were retrospectively analyzed. Explore the total number of lymph nodes and the number of negative lymph nodes and prognosis. Results A total of 182 cases were followed up with a follow-up rate of 80.2%. There were 76 cases without lymph node metastasis, the 3-year and 5-year survival rates were 28.9% and 21.0%, respectively. The total number of lymph nodes was an independent factor affecting the prognosis. In 106 patients with lymph node metastasis, the 3-year and 5-year survival rates were 21.1% and 7.5% respectively. The total number of lymph nodes and the number of negative nodes are independent prognostic factors. There was a significant correlation between the total number of lymph nodes and the number of negative lymph nodes (r = 0.919, P <0.05). Conclusion Under the premise of standardization of radical surgery, the total number of lymph nodes and the number of negative nodes can be used as a prognostic indicator of TNM staging in patients with pancreatic cancer so that patients can obtain more accurate clinical staging and prognosis, in order to obtain the best long-term efficacy .