论文部分内容阅读
由于吡喹酮兴奋与挛缩血吸虫可能不是通过5-羟色胺起作用,故又用药物分析的方法探讨吡喹酮对血吸虫的作用方式。自感染血吸虫尾蚴达6～7周的家兔体内取虫,作体外培养,然后加入吡喹酮和其它药物进行观察。结果,低浓度(3.3×10~(-9)M 和1.6×10~(-8)M)的吡喹酮具有明显增强5-羟色胺和阿托品兴奋血吸虫的作用;吡喹酮(1.6×10~(-6)M)的兴奋作用可为5-羟色胺阻断剂肉桂硫胺(1×10~(-3)～1×10~(-4)M)所拮抗;先用5-羟色胺释放剂盐酸丙咪嗪处理的血吸虫,
Because of praziquantel excitability and contracture Schistosoma japonicum may not play a role through the serotonin, it is also the method of drug analysis of praziquantel on schistosomiasis mode of action. Infected with Schistosoma japonicum cercariae up to 6 to 7 weeks in vivo rabbits take worms for in vitro culture, and then add praziquantel and other drugs were observed. As a result, praziquantel at low concentration (3.3 × 10 -9 M and 1.6 × 10 -8 M) significantly enhanced the activity of serotonin and atropine on schistosomiasis. Praziquantel (1.6 × 10 ~ (-6) M) was antagonized by serotonin (1 × 10 -3 ~1 × 10 -4) M, a serotonin blocking agent. Imipramine hydrochloride-treated schistosomes,