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目的探讨检测维吾尔族心力衰竭(CHF)患者血浆N末端脑钠肽前体(NT-proBNP)水平的临床意义。方法 78例维吾尔族心衰患者根据纽约心脏病协会(NYHA)分级标准分为心功能Ⅰ级(A组8例),Ⅱ级(B组19例),Ⅲ级(C组23例)及Ⅳ级(D组28例)4组,健康对照组51例。用电化学发光法检测NT-proBNP血浆浓度,心脏彩超检测其射血分数。结果心衰患者血浆NT-proBNP水平明显高于正常对照组[(6 329.7±4 697.4比77.9±53.8)pg/m l,P<0.001];不同NYHA心功能分级患者的血浆NT-proBNP浓度比较,可见两者随心功能级别增加而显著升高,且与汉族相同心功能分级无显著性差异。结论血浆中NT-proBNP水平可判断患者是否存在心衰可能;可作为维吾尔族患者心功能不全的检测指标,可判断心衰严重程度及指导临床治疗的指标。
Objective To investigate the clinical significance of detecting plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) level in patients with heart failure (CHF) in Uighur. Methods 78 cases of Uyghur heart failure patients were divided into three groups according to the New York Heart Association (NYHA) grading criteria: group Ⅰ (8 cases), class Ⅱ (group B: 19 cases), class Ⅲ (group C: 23 cases) Grade (28 cases in group D), and healthy control group (n = 51). The plasma concentration of NT-proBNP was detected by electrochemiluminescence and the ejection fraction was measured by echocardiography. Results The plasma levels of NT-proBNP in patients with heart failure were significantly higher than those in the normal controls [(6 329.7 ± 4 697.4 vs 77.9 ± 53.8) pg / ml, P <0.001] It can be seen that both of them increased significantly with the increase of cardiac function level, and there was no significant difference between them in the same classification of cardiac function. Conclusion Plasma NT-proBNP level can determine the possibility of heart failure in patients with Uygur patients can be used as a detection of cardiac dysfunction, can determine the severity of heart failure and guide the clinical treatment of indicators.