原发性干燥综合征(p SS)是一种主要侵犯唾液腺和泪腺等外分泌腺,并累及多个系统的慢性自身免疫性疾病。B细胞异常改变是p SS的主要特征之一,其他特征还包括B细胞过表达、外周血产生大量异常的自身抗体、出现高丙种球蛋白血症、B细胞亚群异常,选择性浸润外分泌腺等组织、形成异位淋巴样组织。调节性B细胞是B淋巴细胞中具有负向免疫调节功能的亚群。调节性B细胞主要通过分泌细胞因子如:IL-10、TGF-β、Foxp3等及与T细胞直接接触等参与固有及适应性免疫应答,抑制炎症反应。调节性B细胞在原发性干燥综合征表达及功能异常可导致原发性干燥综合征的发病。 Primary Sjogren’s syndrome (SS) is a chronic autoimmune disease that affects multiple systems, mainly exocrine glands such as the salivary gland and lacrimal gland. Abnormal changes in B cells are one of the main features of p SS. Other features include over-expression of B cells, abnormal production of autoantibodies in peripheral blood, hypergammaglobulinemia, abnormal B cell subsets and selective infiltration of exocrine glands And other organizations, the formation of ectopic lymphoid tissue. Regulatory B cells are a subset of B lymphocytes that have negative immunomodulatory functions. Regulatory B cells inhibit the inflammatory response mainly through the secretion of cytokines such as IL-10, TGF-β, Foxp3, etc. and their direct contact with T cells. Regulatory B cells in primary Sjogren syndrome expression and dysfunction can lead to the incidence of Sjogren’s syndrome.