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目的 :探讨肿瘤标记物联合检测在胰腺癌诊断及判断预后中的价值。方法 :分别用 EL ISA法检测糖抗原 - 199(CA- 199)、胰腺癌胚抗原 (PEA ) ,用比色法检测恶性肿瘤特异性生长因子 (TSGF)。结果 :48例胰腺癌患者 CA - 199、PEA、TSGF含量均明显升高 ,阳性率分别为 :85 .4%、87.5 %和 83.3% ,三者联合检测诊断胰腺癌的阳性率为 10 0 %。胰腺癌患者根治手术后三指标明显降低 ,与术前比较差异显著 (P<0 .0 1)。结论 :CA- 199、PEA、TSGF动态检测是诊断胰腺癌、观察胰腺癌疗效、判断预后的重要指标 ,三者联合可明显提高胰腺癌诊断的阳性率。
Objective: To explore the value of joint detection of tumor markers in the diagnosis and prognosis of pancreatic cancer. Methods: The glycogen antigen - 199 (CA - 199) and pancreatic carcinoembryonic antigen (PEA) were detected by ELISA, and the tumor - specific growth factor (TSGF) was detected by colorimetric assay. Results: The contents of CA - 199, PEA and TSGF in 48 patients with pancreatic cancer were significantly increased, the positive rates were 85.4%, 87.5% and 83.3% respectively. The positive rate of combined detection of pancreatic cancer and pancreatic cancer was 100% . The three indexes in patients with pancreatic cancer after radical operation were significantly lower than those before operation (P <0.01). Conclusion: The dynamic detection of CA-199, PEA and TSGF is an important index for the diagnosis of pancreatic cancer and the curative effect of pancreatic cancer and prognosis. The combination of the three can obviously improve the positive rate of diagnosis of pancreatic cancer.